West Ham midfielder Adem Ojeleye was left nursing a shoulder injury in a 3-0 defeat by Bordeaux on Tuesday evening, and it was not enough to stop the Hammers’ hopes of qualification for the Champions League this season from slipping away.
Ojeleyo sustained a bone bruise during the first half, which required surgery.
The Hammers were also without midfielder Alex Song, who has been suspended after failing a medical.
It was a similar story for goalkeeper Adrian Lopez, who limped off in the second half.
He did not return and did not make the trip to Stade de France to take part in the final.
It is understood that Oje, who was brought in as a replacement for the injured Song, was also affected by the injury and will be out of action for several weeks.
The French side, who were led by striker Pierre-Emerick Aubameyang, had an early goal on their side when Lopez headed home a Gabriel Paulista cross after the Hambers had scored their first goal in eight games.
However, the home side were unable to find a way past a pair of Bordeaus, with Adem Nacerba headed home by Lopez after he was played through the Hamlets defence by Bauza.
The hosts have not won in France since the 2009-10 season, and they were beaten 2-0 at home by Olympique Marseille last season.
West Ham are in third place in the Premier League with 25 points from 21 games, but they are still without top scorer Mohamed Diame, who will not play in the Champions Cup.
Meanwhile, the West Ham players will be hoping to return to training next week for the first time since the Europa League last 16 tie against Bordeau on January 22.